Lymphoproliferative disorders
Lymphoproliferative disorders are a set of disorders characterized by the abnormal proliferation of lymphocytes into a monoclonal lymphocytosis. The two major types of lymphocytes are B cells and T cells, which are derived from pluripotent hematopoetic stem cells in the bone marrow.
Epstein-Barr virus 1) is associated with a broad spectrum of lymphoproliferative disorders, and is detectable in ≈ 30–50% of systemic lymphomas; however, it has been associated with almost 100% of Primary central nervous system lymphoma 2), especially AIDS-related cases 3).
1)
Hochberg FH, Miller G, Schooley RT, et al. Central-
Nervous-System Lymphoma Related to Epstein-Barr
Virus. N Engl J Med. 1983; 309:745–748
2)
MacMahon EME, Glass JD, Hayward SD, et al.
Epstein-Barr Virus in AIDS-Related Primary Central
Nervous System Lymphoma. Lancet. 1991; 338:
969–973
3)
Burger PC, Scheithauer BW, Vogel FS. Surgical
Pathology of the Nervous System and Its Coverings.
4th ed. New York: Churchill Livingstone; 2002