Lung cancer brain metastases

• Cesium-131 collagen tile brachytherapy for salvage of recurrent intracranial metastases
• Postoperative hydrocephalus in patients with infratentorial brain metastases may be influenced by preoperative treatment: a single-center cohort study
• Prognosis of Brain Metastases (BM) Patient Received Whole Brain Radiation Therapy (WBRT) alone or in combination with Surgery at Dharmais National Cancer Center, Indonesia
• Matching-Adjusted Indirect Comparison of Sotorasib Versus Adagrasib in Previously Treated Advanced/Metastatic Non-Small Cell Lung Cancer Harboring KRAS G12C Mutation
• Genomic profiling and prognostic factors of leptomeningeal metastasis in EGFR-mutant NSCLC after resistant to third-generation EGFR-tyrosine kinase inhibitors
• Effect of Whole-Brain Radiotherapy Dose on the Occurrence of Otitis Media and Mastoiditis in Patients With Lung Cancer With Brain Metastasis
• Independent Prognostic Factors of Survival in Elderly Patients Undergoing Surgery for Non-small Cell Lung Cancer Brain Metastases: Assessing Surgical Eligibility
• Clinicopathological features and prognostic significance of site-specific metastasis in gastric cancer: a population-based, propensity score-matched analysis

see Non-Small cell lung cancer intracranial metastases.

see Small cell lung cancer intracranial metastases.

PET scan

Chest CT

Bone scan

Brain CT

Cranial magnetic resonance imaging

Sun et al. applied single-cell RNA sequencing to profile immune and nonimmune cells in 4 glioma and 10 lung cancer samples.

The analysis revealed that tumor microenvironment (TME) cells are present in heterogeneous subpopulations. Lung cancer reprogrammed cells into immunosuppressed state, including microglia, macrophages, endothelial cells, and CD8+ T cells, with unique cell proportions and gene signatures. Particularly, they identified that a subset of macrophages was associated with poor prognosis. ROS (reactive oxygen species)-producing neutrophils was found to participant in angiogenesis. Furthermore, endothelial cells participated in active communication with fibroblasts. Metastatic epithelial cells exhibited high heterogeneity in chromosomal instability (CIN) and cell population.

Findings provide a comprehensive understanding of the heterogenicity of the tumor microenvironment and tumor cells and it will be crucial for successful immunotherapy development for lung cancer intracranial metastases ¹⁾.

see Lung cancer intracranial metastases treatment.