Lumbar disc degeneration (LDD)

• Effects of Noise Reduction on the Physical and Mental State of Patients with Lumbar Disc Herniation in an Orthopedic Outpatient Clinic
• Crosstalk between osteoporosis and fat-infiltrated psoas at the upper lumbar levels
• Cell-Free Fat Extract for the Treatment of Lumbar Disc Degeneration: A Novel Approach Using Adipose-Derived Biologic
• Finite Element Analysis of Biomechanical Assessment: Traditional Bilateral Pedicle Screw System vs. Novel Reverse Transdiscal Screw System for Lumbar Degenerative Disc Disease
• The Potential Role of the Posterior Elements in Lumbar Spine Laminoplasty to Protect the Intervertebral Disc and Improve Walking Ability-Retrospective Comparative Study
• A study on the correlation between preoperative vitamin D levels and postoperative pain and quality of life in middle-aged and young patients with lumbar degenerative diseases
• Clinical evaluation and finite element analysis of bone cement-augmented anterolateral screw fixation versus percutaneous bilateral pedicle screw fixation co-applied with oblique lumbar interbody fusion for single-level lumbar degenerative diseases with osteoporosis
• The T4-L1-Hip Axis Objectifies the Roussouly Classification Using Continuous Measures

One of the major causes of Low Back Pain is lumbar disc degeneration.

Lumbar disc degeneration (LDD) is associated with both genetic and environmental factors and affects many people worldwide. A hallmark of LDD is loss of proteoglycan and water content in the nucleus pulposus of intervertebral discs. While some genetic determinants have been reported, the etiology of LDD is largely unknown.

The findings from linkage and association studies on a total of 32,642 subjects consisting of 4,043 LDD cases and 28,599 control subjects, identified carbohydrate sulfotransferase 3 (CHST3), as a susceptibility gene for LDD.

The etiology of LDD is not fully understood and is undoubtedly multifactorial. Contributing factors such as body weight, mechanical loading, physical activities, nutritional imbalances, and genetics have all been implicated. More recently, familial predisposition and twin studies have demonstrated a significant genetic contribution, with heritability estimates as high as 74%, but population cohort data on specific genes are lacking ¹⁾.

See Intervertebral disc degeneration classification

carbohydrate sulfotransferase 3 (CHST3).