High-grade glioma epidemiology

High-grade gliomas (HGGs) constitute the most common and aggressive primary brain tumor

High-grade gliomas are the most common primary malignant brain tumor in adults 1) 2) 3).

The top three most common sites for high-grade gliomas in the central nervous system involve the frontal lobe (25.9%), the temporal lobe (19.8%), and other brain areas (19.4%) 4).


They represent a widely heterogeneous group of tumors, the most frequent of which is glioblastoma.

see Glioblastoma epidemiology.

Its annual incidence has risen over the last decades, particularly amongst elderly people.

Approximately 89,000 new primary brain tumors are diagnosed in the United States each year, for which 27% are gliomas and 32.8% are malignant gliomas 5).


1)
DeAngelis LM. Brain tumors. N Engl J Med. 2001;344(2):114–123.
2)
Deorah S, Lynch CF, Sibenaller ZA, Ryken TC. Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001. Neurosurg Focus. 2006;20(4):E1.
3)
Surawicz TS, Davis F, Freels S, Laws ER Jr, Menck HR. Brain tumor survival: results from the National Cancer Data Base. J Neurooncol. 1998;40(2):151–160.
4)
Louis DN, Ohgaki H, Wiestler OD, et al.: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007, 114:97-109. 10.1007/s00401-007-0243-4
5)
Ostrom QT, Gittleman H, Fulop J, Liu M, Blanda R, Kromer C, Wolinsky Y, Kruchko C, Barnholtz-Sloan JS. CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012. Neuro Oncol. 2015 Oct;17 Suppl 4:iv1-iv62. doi: 10.1093/neuonc/nov189. Epub 2015 Oct 27. PubMed PMID: 26511214; PubMed Central PMCID: PMC4623240.
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