High-Grade Glioma Diagnosis
see Glioma Diagnosis.
Results highlighted the role of PTX3 and TIMP1 which were previously considered in Gliomagenesis as well as LTF as a new potential biomarker 1).
Neurite orientation dispersion (NODDI) seems to be useful in reflecting the high-grade glioma infiltration to corticospinal tract (CST), and can evaluate the CST destruction with a performance similar to DTI by providing additional information about neurite density for HGG-induced CST injury 2).
Fujioka et al. established a novel, non-invasive molecular diagnostics using a chip-based digital PCR system targeting circulating tumor DNA derived from CSF with high sensitivity and specificity, especially for high-grade gliomas 3).
Usually, low-grade gliomas show no increase in tumor rCBV, whereas high-grade gliomas demonstrate high relative cerebral blood volume (rCBV) that in some cases even extends outside the contrast-enhancing portions of the tumor 4).
see Stereotactic biopsy of high-grade glioma.
They require MGMT, isocitrate dehydrogenase (IDH) and 1p/19q co-deletion status, the determination of these molecular diagnostics should be prioritized