Granulomatosis with polyangiitis (GPA), formerly known as Wegener granulomatosis, is a rare multisystem autoimmune disease of unknown etiology. Its hallmark features include necrotizing granulomatous inflammation and pauci-immune vasculitis in small- and medium-sized blood vessels
A case of rhombencephalitis with meningitis in a 36-years-old previously healthy man; neurological signs and symptoms were initially consistent with a diagnosis of Wallenberg syndrome. Analysis of cerebrospinal fluid showed predominantly lymphocytic pleocytosis and elevated protein levels. A CT brain scan was normal. MRI of the brain showed a hypertensive type lesion in T2, in the right pontomedullary region that suggested inflammation. A blood culture grew Listeria monocytogenes. The patient improved and fully recovered with appropriate antibiotic treatment. Listeria monocytogenes is a recognized cause of acute brainstem meningoencephalitis. Differential diagnoses that must be considered are other forms of purulent meningitis, viral meningoencephalitis, granulomatosis infections of the central nervous system and, occasionally, stroke 1).