Glycyrrhizin
Glycyrrhizin can reduce secondary brain injury and improve outcomes in rat following traumatic brain injury (TBI) by down-regulation of HMGB1/HMGB1 receptors (TLR4 and RAGE)/NF-κB-mediated inflammatory responses in the injured rat brain 1).
1)
Gu XJ, Xu J, Ma BY, Chen G, Gu PY, Wei D, Hu WX. Effect of glycyrrhizin on
traumatic brain injury in rats and its mechanism. Chin J Traumatol. 2014 Feb
1;17(1):1-7. PubMed PMID: 24506915.