Glioblastoma invasion mechanism

Contains an intricate network of interactions and signaling pathways with the extracellular matrix. Among these related molecules, TGF-β, the ECM, Akt, and microRNAs are most significant in terms of cellular procedures related to Glioblastoma motility and invasion. Musashi-1 (MSI1), a neural RNA-binding protein (RBP), regulates Glioblastoma motility and invasion, maintains stem cell populations in Glioblastoma, and promotes drug-resistant Glioblastoma phenotypes by stimulating necessary oncogenic signaling pathways through binding and regulating mRNA stability. Importantly, these necessary oncogenic signaling pathways have a close connection with TGF-β, ECM, and Akt. Thus, it appears promising to find MSI-specific inhibitors or RNA interference-based treatments to prevent the actions of these molecules despite using RBPs, which are known as hard therapeutic targets. ¹⁾.