Endostatin [Neurosurgery Wiki]

Endostatin is a naturally-occurring, 20-kDa C terminal fragment derived from type XVIII collagen. It is reported to serve as an antiangiogenic agent, similar to angiostatin and thrombospondin.

Endostatin is a broad-spectrum antiangiogenic and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth factor (bFGF/FGF-2) and vascular endothelial growth factor (VEGF).

Gene therapy with endostatin delivered via Semliki Forest virus may be a candidate for the development of a new treatment for brain tumors ¹⁾.

A study demonstrates the potential efficacy of intramuscular delivery of antiangiogenic gene for treatment of metastatic brain tumor ²⁾.

Results indicate a positive correlation between the levels of tissue endostatin and malignancy grades in gliomas. The endostatin may be released near the tumor blood vessels with hyperplasia to counteract angiogenic stimuli in malignant gliomas ³⁾

The cloning, expression and preliminary application of human endostatin protein lay the foundation for the antiangiogenesis therapy of glioma and the other solid tumors ⁴⁾

Encapsulated endostatin-secreting cells are effective for the treatment of human glioblastoma xenografts. Continuous local delivery of endostatin may offer an effective therapeutic approach to the treatment of a variety of tumor types ⁵⁾.

¹⁾

Yamanaka R, Tanaka R. Gene therapy of brain tumor with endostatin. Drugs Today (Barc). 2004 Nov;40(11):931-4. Review. PubMed PMID: 15645005.

²⁾

Oga M, Takenaga K, Sato Y, Nakajima H, Koshikawa N, Osato K, Sakiyama S. Inhibition of metastatic brain tumor growth by intramuscular administration of the endostatin gene. Int J Oncol. 2003 Jul;23(1):73-9. PubMed PMID: 12792778.

³⁾

Morimoto T, Aoyagi M, Tamaki M, Yoshino Y, Hori H, Duan L, Yano T, Shibata M, Ohno K, Hirakawa K, Yamaguchi N. Increased levels of tissue endostatin in human malignant gliomas. Clin Cancer Res. 2002 Sep;8(9):2933-8. PubMed PMID: 12231538.

⁴⁾

Zhang X, Wu J, Fei Z. [Research of cloning, expression of human endostatin gene and its inhibition effects to the glioma in vivo]. Zhonghua Yi Xue Za Zhi. 2001 Jul 10;81(13):783-7. Chinese. PubMed PMID: 11798965.

⁵⁾

Joki T, Machluf M, Atala A, Zhu J, Seyfried NT, Dunn IF, Abe T, Carroll RS, Black PM. Continuous release of endostatin from microencapsulated engineered cells for tumor therapy. Nat Biotechnol. 2001 Jan;19(1):35-9. PubMed PMID: 11135549.