Ehlers–Danlos syndrome

Ehlers–Danlos syndromes (EDS) are a group of genetic connective tissue disorders.

Symptoms may include loose joints, stretchy skin, and abnormal scar formation.

These can be noticed at birth or in early childhood.

Complications may include aortic dissection, joint dislocations, scoliosis, chronic pain, or early osteoarthritis.

The underlying cause of spontaneous intracranial hypotension is usually a spontaneous cerebrospinal fluid fistula, however, some cases may be due to low cerebrospinal fluid volume. Evidence supports an underlying weakness of the meninges as a contributing factor; for instance, connective tissue disorders like Marfan syndrome, and Ehlers-Danlos syndrome.