Cyclic seizure

Cyclic seizures (CS) are common in critically ill patients with acute/progressive brain injury.

CS is often accompanied by synchronous infraslow oscillations of the EEG baseline on DC recordings.

Pregabalin was associated with a relative reduction in seizure burden in neurocritical ill patients with recurrent seizures, especially those with cyclic seizures, and may be considered in the therapeutic arsenal for refractory seizures. Whether this effect is mediated via modulation of spreading depolarization requires further study ¹⁾.