RAF proto oncogene serine threonine protein kinase also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1 is an enzyme that in humans is encoded by the RAF1 gene.

The c-Raf protein is part of the ERK1/2 pathway as a MAP kinase kinase kinase (MAP3K) that functions downstream of the Ras subfamily of membrane associated GTPases.

C-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases, from the TKL (Tyrosine-kinase-like) group of kinases.