Closed loop deep brain stimulation

A closed loop deep brain stimulation (CLDBS) system automatically adjusts stimulation parameters by the brain response in real-time. The CLDBS continues to evolve due to the advancement in brain stimulation technologies.

Deep brain stimulation (DBS) has advanced treatment options for a variety of neurologic and neuropsychiatric conditions. As the technology for DBS continues to progress, treatment efficacy will continue to improve and disease indications will expand. Hardware advances such as longer-lasting batteries will reduce the frequency of battery replacement and segmented leads will facilitate improvements in the effectiveness of stimulation and have the potential to minimize stimulation side effects. Targeting advances such as specialized imaging sequences and “connectomics” will facilitate improved accuracy for lead positioning and trajectory planning. Software advances such as closed-loop stimulation and remote programming will enable DBS to be a more personalized and accessible technology ¹⁾.

Embedded closed loop deep brain stimulation was feasible, safe, and had a comparable outcome to conventional TS DBS for the treatment of tics ²⁾.

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Frey J, Cagle J, Johnson KA, Wong JK, Hilliard JD, Butson CR, Okun MS, de Hemptinne C. Past, Present, and Future of Deep Brain Stimulation: Hardware, Software, Imaging, Physiology and Novel Approaches. Front Neurol. 2022 Mar 9;13:825178. doi: 10.3389/fneur.2022.825178. PMID: 35356461; PMCID: PMC8959612.

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Cagle JN, Okun MS, Cernera S, Eisinger RS, Opri E, Bowers D, Ward H, Foote KD, Gunduz A. Embedded Human Closed-Loop Deep Brain Stimulation for Tourette Syndrome: A Nonrandomized Controlled Trial. JAMA Neurol. 2022 Sep 12. doi: 10.1001/jamaneurol.2022.2741. Epub ahead of print. PMID: 36094652.