Cingulate gyrus glioma classification
95 consecutive adult cases of primary cingulate gyrus gliomas that all underwent craniotomies and tumor resection. The patients were classified into unitary sub-region based on the four-division model. The information on clinical symptoms, pathology, EOR, postoperative neurological outcome, and survival was analyzed through group comparison.
Low-grade gliomas (LGGs) were more prevalent (69.47%) for the cingulate gyrus. Diffuse astrocytoma (40.00%) was the most common histopathological diagnosis in total. Regarding sub-regions tumor involvement, midcingulate cortex (MCC) glioma was most prevalent (54.74%) followed by anterior cingulate cortex (ACC) glioma. Among all patients, 83 patients (87.37%) received EOR ≥ 90%. In the LGG group, 58 patients (87.88%) received EOR ≥ 90%. The achievement of EOR significantly correlated with survival (P = 0.006). MCC cases were significantly associated with short-term morbidity in either language or motor function (P = 0.02). The majority of ACC cases (80.65%) escaped from any short-term deficits and nearly 90% were free of permanent morbidity. Tumors in the dominant hemisphere were significantly associated with language dysfunction or cognition dysfunction, either short-term (P=0.0006) or long-term morbidity (P=0.0111). Age was the only postoperative susceptible predictor for all types of transient (P=0.021) and permanent (P=0.02) neurological deficits.
Regarding cingulate gyrus glioma, the management of surgical plans could be carried out in four sub-region levels. Despite short-term neurological dysfunction caused by surgical procedures, the majority of transient dysfunction could be relieved or recovered in long term. The necessary effort to prolong overall survival is still to achieve advisable EOR 1).
Tumors were classified as low-grade gliomas in 11 cases (29%). A glioblastoma multiforme (WHO Grade IV, 10 cases [26%]) and oligoastrocytoma (WHO Grade III, 9 cases [24%]) were the most frequent histopathological results. 2).