Chondroitinase ABC is an enzyme that breaks down complex sugars called glycosaminoglycans (GAGs), specifically chondroitin sulfate and dermatan sulfate, which are important components of the extracellular matrix in connective tissues such as cartilage and the spinal cord. Chondroitinase ABC is produced by certain bacteria and is commonly used in scientific research to study the role of GAGs in biological processes.

In medicine, chondroitinase ABC is being investigated as a potential treatment for various conditions, including spinal cord injury, multiple sclerosis, and lumbar spinal stenosis. In the case of lumbar spinal stenosis, chondroitinase ABC is injected into the spinal canal to break down GAGs that contribute to the narrowing of the spinal canal and compression of the spinal nerves. This can relieve pain and other symptoms associated with the condition.

While research on chondroitinase ABC is ongoing, it is not yet approved as a standard treatment for any medical condition. Its use in experimental treatments is limited and should be discussed with a qualified healthcare professional