Cerebral central core

The cerebral central core (CCC) is a topographical area located between the sylvian cistern laterally and the third ventricle medially. It has been described as a block that rests over the midbrain. It includes the insular cortex, extreme capsule, claustrum, external capsule, lenticular nucleus, internal capsule, caudate nucleus, and thalamus. In addition, it is surrounded by a group of short and long association commissural and projection fibers. This white substance, located between the peri-insular and lateral ventricle grooves, is known as the cerebral isthmus 1). It connects the nucleus of the central core with the rest of the hemisphere. It also anatomically separates the sylvian cistern from the ventricular system. As the topographic center of the brain, it integrates various types of sensitive, motor, cognitive, and emotional information. A few investigators 2) 3) 4) have recognized the CCC as a different region in the brain and highlight the importance of surgical planning. From a strictly neurosurgical point of view, its differentiation will be useful, because it contains eloquent structures of deep localization, with complex cisternal and ventricular relationships. Thus, Baldoncini et al. divided the CCC and proposed different neurosurgical approaches for each sector for the pathological entities located within this important anatomical region 5)

If the insula behaves as an external shield to the CCC 6) and the latter is located above the brainstem, one can easily understand that the approaches to this topographic sector will represent a great challenge. In addition, the CCC includes numerous eloquent cortical and subcortical structures. Therefore, the preoperative studies of each case must be carefully analyzed to understand the lesion’s relationship to the location and, thus, enable selection of the most accurate and safe approach.

For those lesions with a lateral ependymal component in the lateral ventricle, the contralateral transcallosal access will provides a greater angle of vision 7) 8) without the need for retraction of the cingulate gyrus and fascicle.


1)
Koutsarnakis C, Liakos F, Liouta E, Themistoklis K, Sakas D, Stranjalis G. The cerebral isthmus: fiber tract anatomy, functional significance, and surgical considerations. J Neurosurg. 2015 Sep 11:1-13. [Epub ahead of print] PubMed PMID: 26361277.
2) , 6)
Ribas GC, de Oliveira E. A insula e o conceito de bloco cerebral central. Arq Neuropsiquiatr. 2007;65: 92-100.
3)
Brodal A. Neurological Anatomy in Relation to Clinical Medicine. 3rd ed. New York: Oxford University Press; 1981.
4)
Ribas EC, Yağmurlu K, de Oliveira E, Ribas GC, Rhoton A Jr. Microsurgical anatomy of the central core of the brain. J Neurosurg. 2018;129:752-769.
7)
Baldoncini M, González López P. Abordaje Interhemisférico Contralateral Transfalcino, Subfalcino y Transcalloso. Rev Argentina Neurocir. 2018;32:1-15.
8)
Lawton MT, Golfinos JG, Spetzler RF. The contralateral transcallosal approach experience with 32 patients. Neurosurgery. 1996;39:729-735.
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