cerebellar_cognitive_affective_syndrome

Cerebellar Cognitive Affective Syndrome

The cerebellum is traditionally associated with motor coordination, but modern neuroscience has revealed its key role in cognition and emotion.

Coined by Schmahmann and Sherman (1998), this syndrome includes:

  • Executive dysfunction: impaired planning, working memory, abstract reasoning.
  • Spatial disorganization: visuospatial deficits.
  • Language impairments: dysprosody, anomia, agrammatism.
  • Personality changes: apathy, disinhibition, emotional flattening.

This constellation is described as dysmetria of thought—a cognitive equivalent to motor dysmetria.

  • Cerebro-cerebellar loops: The dentate nucleus communicates with prefrontal, parietal, and limbic cortices via thalamic relays.
  • Neuroimaging evidence:
    • fMRI and PET show cerebellar activation during:
      • Language tasks (especially right cerebellar hemisphere).
      • Working memory tasks.
      • Emotion processing.
      • Social cognition.
Domain Manifestation of Cerebellar Dysfunction
Executive function Disorganized thought, impaired reasoning
Language Poor verbal fluency, word-finding issues
Visuospatial skills Constructional apraxia, disorientation
Emotion and affect Apathy, irritability, emotional blunting
Social cognition Difficulty interpreting emotions/intentions
  • Neurodevelopment: Implicated in Autism Spectrum Disorder (ASD), ADHD.
  • Psychiatry: Functional abnormalities linked to schizophrenia, depression, bipolar disorder.
  • Surgical relevance: Post-operative CCAS may occur after posterior fossa surgery, especially in children (e.g. cerebellar mutism syndrome).

The cerebellum plays a critical modulatory role across motor, cognitive, and affective domains. It acts as a universal calibrator—coordinating not just movement, but also thought and emotion.

  • cerebellar_cognitive_affective_syndrome.txt
  • Last modified: 2025/07/10 13:53
  • by administrador