Central Hypothyroidism

Central hypothyroidism refers to thyroid hormone deficiency due to a disorder of the pituitary, hypothalamus, or hypothalamic-pituitary portal circulation, resulting in diminished thyroid-stimulating hormone (TSH), thyrotropin-releasing hormone (TRH), or both.

Aqueductal stenosis in adulthood.

Hypothalamic hamartomas

The most frequent cause of central hypothyroidism (CeH) is pituitary neuroendocrine tumors, but the mechanisms remain unclear.

see Central Hypothyroidism in Acromegaly.