CD147
The CD147 protein is a ubiquitous multifunctional membrane receptor. Expression of CD147, which is regulated by sterol carrier protein, reportedly modulates amyloid beta (Aβ), the neurotoxic peptide implicated in neuronal degeneration in Alzheimer disease (AD).
In glioma, temozolomide resistance is due to overexpression of CD147 protein and induction of Nuclear factor-erythroid 2 related factor 2 1)
Findings reveal potentially important relationships between cholesterol loading, CD147 expression, Aβ toxicity, and the putative involvement of CYPA protein in neuroprotection in AD 2).
1)
Luo GQ, Bai S, Hu Y, Chen H, Yan ZJ, Fan LL. CD147 Protein Expression and Temozolomide Resistance in Glioma Cells: An Ex vivo and In vivo Study. Cell Mol Biol (Noisy-le-grand). 2022 Jul 31;68(7):160-164. doi: 10.14715/cmb/2022.68.7.26. PMID: 36495502.
2)
Kanyenda LJ, Verdile G, Martins R, Meloni BP, Chieng J, Mastaglia F, Laws SM,
Anderton RS, Boulos S. Is cholesterol and amyloid-β stress induced CD147
expression a protective response? Evidence that extracellular cyclophilin a
mediated neuroprotection is reliant on CD147. J Alzheimers Dis.
2014;39(3):545-56. doi: 10.3233/JAD-131442. PubMed PMID: 24217276.