Calcitonin gene-related peptide

Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides, which in humans exists in two forms: α-CGRP and β-CGRP, also known as CGRP I and CGRP II.

α-CGRP is a 37-amino acid neuropeptide and is formed from the alternative splicing of the calcitonin/CGRP gene located on chromosome 11. β-CGRP is less studied. In humans, β-CGRP differs from the α-CGRP by three amino acids and is encoded in a separate gene within the same vicinity.

The CGRP family includes calcitonin (CT), adrenomedullin (AM), and amylin (AMY).

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