Bulk flow model

The classic bulk flow model of CSF ascribes discrete sites of cerebrospinal fluid production, cerebrospinal fluid absorption, as well as cerebrospinal fluid circulation routes. While this model may be useful for understanding and treating some aspects of CSF, it is becoming clear that it is inadequate to explain many of the details. Pulsatile flow, lymphatic channels (glymphatics) and distributed sites of production and absorption all appear to participate in cerebrospinal fluid dynamics.