BRAF mutation

Certain other inherited BRAF mutations cause birth defects.

BRAF V600E is a subset of the BRAF mutation

Drugs that treat cancers driven by BRAF have been developed. Two of these drugs, vemurafenib and dabrafenib are approved by FDA for the treatment of late-stage melanoma. Vemurafenib was the first drug to come out of fragment-based drug discovery.