Blood component therapy
Massive transfusions
Definition: replacement of > 1 blood volume (in average adult ≈ 20 U) in < 24 hrs for adults, or > 2 × circulating blood volume in peds, may cause dilution of effective platelets and coagulation factors, which requires platelet transfusion and fresh frozen plasma (FFP). When operating on a pediatric patient, you can usually safely replace up to 1.5 × the circulating blood volume before problems with coagulopathy ensue.
Blood component therapy required for massive transfusions:
Red blood cell therapy