Bladder cancer intracranial metastases treatment
The outcome of Bladder cancer intracranial metastases remains guarded. Factors associated with improved survival include intracranial resection. Future, prospective work is needed to further define optimal management 1).
Results indicate that radiation therapy alone is inadequate treatment. Therefore, when possible, Mahmoud-Ahmed et al., advocate more effective treatment by combining radiation therapy with other treatment modalities, as recommended in ongoing clinical trials 2).
Rosenstein et al., recommend that patients with solitary brain lesions and good performance status be aggressively managed with surgical resection and postoperative radiation therapy 3).
1)
Taylor JM, McTyre ER, Tatter SB, Laxton AW, Munley MT, Chan MD, Cramer CK.
Gamma Knife Stereotactic Radiosurgery for the Treatment of Brain Metastases from
Primary Tumors of the Urinary Bladder. Stereotact Funct Neurosurg. 2018 Apr
26:1-5. doi: 10.1159/000488151. [Epub ahead of print] PubMed PMID: 29698968.
2)
Mahmoud-Ahmed AS, Suh JH, Kupelian PA, Klein EA, Peereboom DM, Dreicer R,
Barnett GH. Brain metastases from bladder carcinoma: presentation, treatment and
survival. J Urol. 2002 Jun;167(6):2419-22. PubMed PMID: 11992049.
3)
Rosenstein M, Wallner K, Scher H, Sternberg CN. Treatment of brain metastases
from bladder cancer. J Urol. 1993 Mar;149(3):480-3. PubMed PMID: 8437250.