B-cell CLL/lymphoma 9 like is a protein that in humans is encoded by the BCL9L gene.

Greater matrix stiffness could obviously up-regulate the expression of BCL9L, thereby promoting the activation of Wnt/beta-catenin signaling and ultimately increasing the stemness of glioma cells. Inhibiting Wnt/beta-catenin signaling using gigantol consistently improved the anticancer effects of chemotherapy and radiotherapy in mice with subcutaneous glioma tumors. These findings demonstrate that a stiffer matrix increases the stemness of glioma cells by activating BCL9L/Wnt/beta-catenin signaling. Moreover, they provided a potential strategy for clinical glioma treatment by demonstrating that gigantol can improve the effectiveness of traditional chemotherapy/radiotherapy by suppressing Wnt/beta-catenin signaling ¹⁾.