The Autophagy-related genes (Atg), characterized extensively in yeast, are a set of approximately twenty evolutionarily conserved genes required for autophagy. Autophagy (specifically, macroautophagy) is the process of bulk degradation of cytoplasmic material.

The methylation levels of 6 autophagy-related genes (ARGs) (ARSB, CFLAR, WIPI2, RB1, ERN1, RAB24) have a strong predictive potential for LGG, and the methylation regulation of ARGs has an important impact on the immune microenvironment of LGGs.