Aquaporin 3 (AQP3)
Aquaporin 3 (AQP3) is a member of the aquaglyceroporin subfamily, meaning it facilitates the transport of both water and glycerol across cell membranes.
Where is AQP3 found?
- 🧴 Skin – Keratinocytes in the epidermis
- 💧 Kidneys – Basolateral membrane of collecting ducts
- 🌬️ Respiratory tract
- 🧠 Digestive and immune systems
Main Functions
- Maintains skin hydration and elasticity
- Supports kidney water and solute reabsorption
- Involved in wound healing and inflammation
- Participates in cell migration and proliferation
Clinical Relevance
- 🔻 Decreased AQP3 linked to:
- Dry skin
- Eczema
- Impaired wound healing
- 🔺 Increased AQP3 seen in:
- Certain cancers (gastric, prostate, colon)
- Promotes tumor cell migration