Anorexia nervosa

• Alexithymia and Emotion Recognition Over the Treatment Course in Adolescents and Emerging Adults With Anorexia Nervosa
• The accuracy of early weight gain in predicting treatment outcome in a large outpatient sample of patients with anorexia nervosa
• Improving Understanding, Recognition and Treatment for Men With Anorexia Nervosa
• Virtual Reality- Based Running Exposure To Target The Acute Urge To Be Physically Active In Anorexia Nervosa: A Case Series
• Pharmacotherapy Considerations in Underweight Patients with Anorexia Nervosa: A Narrative Review
• Mortality and hospital admissions in people with eating disorders: longitudinal cohort study in secondary care-linked English primary care records
• Waiting list intervention for adolescents with anorexia nervosa
• Recruitment and retention in the concealed weighing arm of a pilot study comparing weighing methods in the treatment of adults with anorexia nervosa: lessons learned

Often referred to simply as anorexia, is an eating disorder characterized by a low weight, fear of gaining weight, a strong desire to be thin, and food restriction.

Many people with anorexia see themselves as overweight even though they are underweight.

If asked they usually deny they have a problem with low weight. Often they weigh themselves frequently, eat only small amounts, and only eat certain foods. Some will exercise excessively, force themselves to vomit, or use laxatives to produce weight loss. Complications may include osteoporosis, infertility, and heart damage among others. Women will often stop having menstrual periods.

The association of anorexia nervosa (AN) with organic brain lesions may offer insight into underlying illness neuropathology. A systematic review reported an association between AN and lesions located in the right frontal lobe. To date, no studies have studied such a case longitudinally. A case of a male presenting with AN and a frontal lobe glioma is described.

The clinical symptoms and subsequent medical and neuropsychological investigations before and after surgery are RESULTS: The remission of ED symptoms is observed at 2 year post-surgery follow up.

The features of this case are set into the context of recent conceptualizations of AN and the clinical implications for identifying individuals with underlying organic causes ¹⁾.

Anorexia Nervosa Treatment.

Sixteen participants, including eight patients with anorexia nervosa and eight controls, underwent baseline T1-weigthed and diffusion tensor imaging (DTI) acquisitions. Patients received DBS targeting either the subcallosal cingulate (DBS-SCC, N = 4) or the nucleus accumbens (DBS-NAcc, N = 4) based on psychiatric comorbidities and AN subtype. Post-DBS neuroimaging evaluation was conducted in four patients. Data analyses were performed to compare structural connectivity between patients and controls and to assess connectivity changes after DBS intervention.

Baseline findings revealed that structural connectivity is significantly reduced in patients with AN compared to controls, mainly regarding callosal and subcallosal white matter (WM) tracts. Furthermore, pre- vs. post-DBS analyses in AN identified a specific increase after the intervention in two WM tracts: the anterior thalamic radiation and the superior longitudinal fasciculus-parietal bundle.

This study supports that structural connectivity is highly compromised in severe AN. Moreover, this investigation preliminarily reveals that after DBS of the subcallosal cingulate and nucleus accumbens in severe AN, there are white matter (WM) tracts modifications. These microstructural plasticity adaptations may signify a mechanistic underpinning of DBS in this psychiatric disorder ²⁾