Acquired aneuploidy
Acquired aneuploidy was frequently detected in recurrent gliomas and was characterized by IDH mutation but without 1p/19q co-deletion, and further converged with acquired alterations in the cell cycle and poor outcomes. The clonal architecture of each tumor remained similar over time, but the presence of subclonal selection was associated with decreased survival. Finally, there were no differences in the levels of immunoediting between initial and recurrent gliomas. Collectively, the results suggest that the strongest selective pressures occur during early glioma development and that current therapies shape this evolution in a largely stochastic manner 1).
1)
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