Acetylcholine
Botulinum toxin A (BTX-A) inhibits acetylcholine exocytosis from parasympathetic postganglionic nerves to the M2 and M3 receptors of the detrusor, inhibiting detrusor contraction. BTX-A (100– 200u) is injected into the detrusor muscle during cystoscopy. It decreases overactivity, urgency, and storage pressures 1)
1)
Weckx F, Tutolo M, De Ridder D, et al. The role of botulinum toxin A in treating neurogenic bladder. Transl Androl Urol. 2016; 5:63–71