Thalamic CMs often manifest through neurological symptoms such as weakness, sensory disturbances, or seizures. Due to their deep-seated position, even small hemorrhages can lead to noticeable deficits.
The management of thalamic cavernomas remains complex due to the deep-seated location of the lesion and the critical surrounding neurovascular structures. Treatment strategies must be individualized, balancing the risks of intervention against the natural history of the lesion.
Asymptomatic patients or those with lesions discovered incidentally are typically managed conservatively. Observation with serial neuroimaging is appropriate in cases where the lesion is small, non-hemorrhagic, and not causing significant mass effect or neurological deficits. Medical management includes symptomatic treatment for headache, seizures, or hydrocephalus, if present. Antiepileptic drugs may be considered in patients with seizure onset, although seizure control is often less favorable compared to cortical cavernomas.
Microsurgical resection remains the definitive treatment for symptomatic thalamic cavernomas, especially in patients presenting with hemorrhage, progressive neurological deficits, or intractable epilepsy. Surgical candidacy is determined by lesion location (particularly its proximity to safe surgical corridors), evidence of recent or recurrent hemorrhage, and the presence of disabling symptoms. Approaches such as the transcallosal, transventricular, or transcortical routes are selected based on lesion topography. In experienced hands, gross-total resection can result in significant symptomatic relief and hemorrhage prevention, albeit with inherent surgical risks.
Stereotactic radiosurgery (SRS) has been proposed as an alternative for inoperable thalamic cavernomas or patients at high surgical risk. Evidence on its efficacy remains limited and controversial. While some studies report reduced rebleeding rates following SRS, others caution about potential radiation-induced edema or delayed cystic changes. As such, SRS is generally reserved for select cases where surgery is contraindicated.
Given the potential morbidity associated with both the natural history and treatment of thalamic cavernomas, management decisions should be guided by a multidisciplinary team including neurosurgeons, neuroradiologists, neurologists, and radiation oncologists. Risk stratification tools and patient-centered discussions are essential to optimize outcomes 1).
In a systematic review Al-Shalchy et al. focuses on summarizing evidence with respect to their clinical presentation, diagnostic approach, management strategy, and outcome. This review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and included studies from PubMed and Scopus databases. Articles were screened for relevance using predefined inclusion criteria, and data were extracted and synthesized narratively. Quality assessment was performed using the Joanna Briggs Institute checklist. A total of 15 studies involving 219 patients were included. The patients' ages ranged from newborn to 56 years, with a slight predominance of females (N = 121, 55%). Common presentations included hemorrhage (N = 171, 78.1%) and headaches (N = 123, 56.2%). Surgical resection was the most common intervention used; transcallosal approach (N = 40, 18.3%) was the most frequent. Results from pooled analyses revealed distinct trends in surgical decision-making. Approximately 28% of patients were managed conservatively (95% confidence interval [CI]: 0.12-0.43), while 72% underwent surgery (95% CI: 56.2-88.5). Preventative surgeries accounted for 30% of cases (95% CI: 0.15-0.46), whereas surgeries following a first hemorrhagic event were more common (47%; 95% CI: 0.34-0.60). Interestingly, only 5% underwent surgery after recurrent bleeding (95% CI: 0.02-0.08), suggesting a shift toward earlier intervention. Publication bias was largely absent, and findings remained robust across models. These insights highlight evolving trends in surgical timing and underscore the importance of tailored, evidence-based management for thalamic cavernomas 2).
Cavernomas in the thalamus or subcortical cavernoma represent a unique challenge for surgeons in trying to identify and then use a safe corridor to access and resect the pathology.
Previous authors have described specific open microsurgical corridors based on pathology location, often with technical difficulty and morbidity. This series presents 2 cavernomas that were resected using a minimally invasive approach that is less technically demanding and has a good safety profile. The authors report 2 cases of cavernoma: one in the thalamus and brainstem with multiple hemorrhages and the other in eloquent subcortical white matter. These lesions were resected through a transulcal parafascicular approach with a port-based minimally invasive technique. In this series there was complete resection with no neurological complications. The transulcal parafascicular minimally invasive approach relies on image interpretation and trajectory planning, intraoperative navigation, cortical cannulation and subcortical space access, high-quality optics, and resection as key elements to minimize exposure and retraction and maximize tissue preservation. The authors applied this technique to 2 patients with cavernomas in eloquent locations with excellent outcomes 3).