NORDSTEN study



A multicentre randomized controlled trial [the Spinal Stenosis Trial (SST) (part of the NORDSTEN study)] including 465 patients aged 18-80 years with neurogenic claudication or radiating pain and MRI findings indicating lumbar spinal stenosis without spondylolisthesis is performed to compare three posterior decompression techniques: unilateral laminotomy with crossover, bilateral laminotomy, and spinous process osteotomy. The primary outcome is a change in Oswestry Disability Index (ODI 2 years postoperatively). Secondary outcomes are change in EQ-5D, Zurich Claudication Questionnaire, and Numeric Rating Scale for leg pain and back-pain. Also recorded were the Global Perceived Effect score, complications, length of hospital stay, reoperation rate 2 years postoperatively, difference in recurrence of symptoms or postoperative instability, and MRI change in the dural sac area. Further, a 5 and 10 years follow-up is planned with the same outcome measures.

Discussion: Newer and less invasive techniques are increasingly favored in surgery for LSS. This trial will compare the clinical and radiological results of three different techniques and may contribute to better clinical decision-making in the surgical treatment of LSS.

Trial registration: ClinicalTrials.gov reference: NCT02007083 (November 22, 2013) 1).

1)
Aaen J, Banitalebi H, Austevoll IM, Hellum C, Storheim K, Myklebust TÅ, Anvar M, Weber C, Solberg T, Grundnes O, Brisby H, Indrekvam K, Hermansen E. Is the presence of foraminal stenosis associated with outcome in lumbar spinal stenosis patients treated with posterior microsurgical decompression Acta Neurochir (Wien). 2023 Jul 5. doi: 10.1007/s00701-023-05693-5. Epub ahead of print. PMID: 37407851.