Lymphoproliferative disorders are a set of disorders characterized by the abnormal proliferation of lymphocytes into a monoclonal lymphocytosis. The two major types of lymphocytes are B cells and T cells, which are derived from pluripotent hematopoetic stem cells in the bone marrow.
Epstein-Barr virus 1) is associated with a broad spectrum of lymphoproliferative disorders, and is detectable in ≈ 30–50% of systemic lymphomas; however, it has been associated with almost 100% of Primary central nervous system lymphoma 2), especially AIDS-related cases 3).