🧠 Cortistatin (CORT)

A neuropeptide highly homologous to somatostatin.

Also binds somatostatin receptors (SSTRs) but has unique effects, particularly in the immune system and sleep modulation.

Unlike SST, CORT can bind additional receptors, such as ghrelin receptors and Mas-related G protein–coupled receptors (MRGPRs).

Plays a role in modulating sleep, neuronal excitability, and inflammation.