Research or a detailed examination and analysis of a subject.
Cohort study
Prospective study
An experiment In particular, a clinical trial.
Studies (journal)
see imaging study
see clinical trial
Vargas-Caballero et al suggest that replicating elements of research findings from animals and stem cell models in resected human brain tissue would strengthen our understanding of disease mechanisms and the therapeutic strategies and aid translation. The use of human brain tissue alongside induced pluripotent stem cells iPSC-derived neural models can validate molecular mechanisms identified in rodent disease models and strengthen their relevance to humans. If drug target engagement and mechanism of cellular action can be validated in human brain tissue, this will increase the success rate in clinical research. The combined use of resected human brain tissue, alongside iPSC-derived neural models, could be considered a standard step in pre-clinical research and help to bridge the gap to clinical trials 1).