Cancer cell line

• Correlation of miR-3188 with patient prognosis and mechanistic inhibition of glioma proliferation, invasion, and migration by targeting MAPK1
• KLHL7 enhances cell viability and cell cycle progression in glioma via glutamine metabolism by activating the beta-catenin signaling pathway
• Blocking LIF and PD-L1 enhances the antitumor efficacy of SBRT in murine PDAC models
• Mitochondrial dysfunction and cell death induced by Toona sinensis leaf extracts through MEK/ERK signaling in glioblastoma cells
• KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma
• SPP1 + macrophages cause exhaustion of tumor-specific T cells in liver metastases
• Combination therapy of adagrasib and abemaciclib in non-small cell lung cancer brain metastasis models genomically characterized by KRAS-G12C and homozygous loss of CDKN2A
• PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites

A cancer cell line is a population of cancer cells that has been cultured in the laboratory and can continuously grow and divide. These cells originate from a tumor sample taken from a patient and are modified to survive and proliferate indefinitely under lab conditions. They're a crucial tool in cancer research, drug development, and understanding cancer biology.

🔬 Characteristics: Immortalized: Unlike normal cells, they don't undergo senescence (aging).

Genetically unstable: They may accumulate mutations over time.

Homogeneous (sort of): All cells in the line are genetically similar, but some heterogeneity can still emerge.

Adapted to 2D culture: Most are grown in monolayers, although 3D models (e.g., organoids) are increasingly used.

🧪 Common Cancer Cell Lines: Cell Line Cancer Type Origin HeLa Cervical cancer Henrietta Lacks (1951) MCF-7 Breast cancer Human A549 Lung carcinoma Human U87 Glioblastoma Human PC-3 Prostate cancer Human ⚠️ Limitations: May not fully represent real tumors (e.g., tumor microenvironment is absent).

Long-term passaging can change their properties.

Some are contaminated or misidentified (HeLa famously contaminated many lines).

🧰 Applications: Drug screening

Gene editing and CRISPR studies

Tumor biology research

Biomarker discovery

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An immortalized cell line is a population of cells from a multicellular organism that would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division. The cells can therefore be grown for prolonged periods in vitro. The mutations required for immortality can occur naturally or be intentionally induced for experimental purposes. Immortal cell lines are a very important tool for research into the biochemistry and cell biology of multicellular organisms. Immortalised cell lines have also found uses in biotechnology.

https://www.atcc.org/~/media/PDFs/Brain_Tumor_Cell_Lines.ashx

AM-38

GaMg

D-54Mg

CCF-STTG1

SW 1088

SW 1783

CHLA-02-ATRT

A172

U-138 MG

LN-18

LN-229

U87 MG

U-118 MG

T98G

Hs 683

CHLA-01-MED

CHP-212

H4

D341 Med

Daoy

PFSK-1

DBTRG-05MG

M059K

M059J

IMR-32

BC3H1

bEnd.3

Neuro-2a

NB41A3

N1E-115

C6

C6/LacZ

9L/lacZ

C6/lacZ7

F98EGFR

F98npEGFRvIII

F98

RG2

9L gliosarcoma

U251,