Atlanto-axial subluxation (AAS) is a condition where there is abnormal movement or instability between the atlas (C1) and the axis (C2) vertebrae. Treatment depends on the cause, severity, and presence of neurological symptoms.
see Rheumatoid Arthritis treatment
The earlier treatment paradigms of Atlanto-Axial Subluxation treatment focused on transoral excision of the dens followed by posterior instrumented fusion.
The more recent therapies have focused on a single-stage correction using joint distraction or more recently using corrective motions in both the vertical and horizontal axis, thus shifting the attention to the joints.
The shift in philosophy in treatment has also encouraged studies, which have examined various joint parameters (in both cases and controls) and have defined normal and abnormal parameters.
Sagittal joint inclination and craniocervical tilt significantly correlated with both BI and AAD (P < .01). Coronal joint inclination correlated with BI (P = .2). The mean sagittal joint inclination value in control subjects was 87.15 ± 5.65° and in patients with BI and AAD was 127.1 ± 22.05°. The mean craniocervical tilt value in controls was 60.2 ± 9.2° and in patients with BI and AAD was 84.0 ± 15.1°. The mean coronal joint inclination value in control subjects was 110.3 ± 4.23° and in patients with BI and AAD was 121.15 ± 14.6°.
It is a important role of joint orientation and its correlation with the severity of BI and AAD and has described new joint indexes 1).
There are no pharmacologic interventions for atlantoaxial instability (AAI). Because of the chronicity of the instability at the time of presentation in most cases, corticosteroids have little, if any, impact on neurologic findings and may present many undesirable outcomes. In the acute traumatic setting, corticosteroids remain controversial in the literature. Current guidelines provided by the American Academy of Neurological Surgeons (AANS) include level I evidence against the use of corticosteroids or gangliosides in the acute trauma patient.
Unless symptoms of spinal cord compression occur, AAI requires no treatment. Once symptoms arise, cervical spine stabilization is indicated until surgical stabilization is performed.
In persons with rotatory displacement, the time of presentation dictates the treatment. Most of these patients' conditions resolve spontaneously, and additional care is not sought.
Patients presenting with subluxation of less than 1 week's duration are treated with a soft collar and rest for a week. If close follow-up fails to document reduction, a period of halter traction with analgesics and muscle relaxants is warranted. If this fails, halo bracing can be undertaken.
In patients with rotatory displacement of more than 1 month's duration, a period of halo traction for 3 weeks is tried. Usually, two types of patients are in this group: (1) those whose subluxation resolves with bracing but recurs when bracing stops and (2) those who usually present with a fixed deformity.
Toni et al. reported the outcome and complications following atlanto-axial stabilisation by polymethylmethacrylate applied to screws placed using 3D-printed patient-specific drill guides.
Materials and methods: Case series of dogs treated with this technique between May 2016 and August 2018 including pre- and post-operative modified Frankel score, imaging and complications. Screw placement was graded using a modified Zdichavsky classification based on post-operative CT. Telephone follow-up was obtained for surviving dogs.
Results: Twelve cases were included. At presentation, modified Frankel score was 3 in five dogs and 4 in seven dogs on presentation. Of 61 bicortical screws placed, 57 (93%) were fully contained within the pedicle and vertebral body and four (7%) partially breached the medial pedicle wall. Post-operative CT revealed good alignment of C1 and C2 in all planes. Reversible perioperative adverse events were described in five of 12 dogs and two dogs were euthanased shortly after discharge. At 18 to 50 days after surgery eight dogs had improved neurological status. Neurological status remained unchanged in the remaining two dogs. All dogs were reported ambulatory and pain-free at telephone follow-up (median 405 days post-surgery, range 180 to 780 days).
Clinical significance: This technique resulted in safe bicortical screw placement in dogs with atlanto-axial subluxation 2).