swi_snf [Neurosurgery Wiki]

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[[SWI/SNF]]-related matrix-associated actin-dependent regulator of [[chromatin]] subfamily B member 1 is a [[protein]] that in humans is encoded by the [[SMARCB1]] gene.


SWI/SNF (SWItch/Sucrose Non-Fermentable), is a [[nucleosome]] remodeling complex found in both eukaryotes and prokaryotes. In simpler terms, it is a group of proteins that associate to remodel the way DNA is packaged. It is composed of several proteins – products of the [[SWI]] and [[SNF]] genes (SWI1, SWI2/SNF2, SWI3, SWI5, SWI6) as well as other polypeptides.

It possesses a DNA-stimulated ATPase activity and can destabilise histone-DNA interactions in reconstituted nucleosomes in an ATP-dependent manner, though the exact nature of this structural change is unknown.

The human analogs of SWI/SNF are BAF (SWI/SNF-A) and PBAF (SWI/SNF-B). BAF in turn stands for "BRG1- or HBRM-associated factors", and PBAF is for "polybromo-associated BAF".