PTRF [Neurosurgery Wiki]

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====== PTRF ======

{{rss>https://pubmed.ncbi.nlm.nih.gov/rss/search/12GmDGiSiGA-ak78aRs59lEXZiFJfHi7fXZkZpfwXdltuDY9AO/?limit=15&utm_campaign=pubmed-2&fc=20230616051335}}
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===== PTRF in Glioma =====

[[PTRF in glioma]]
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Polymerase I and transcript release factor (PTRF) plays a pivotal role in regulating cellular senescence, glucose intolerance, lipid metabolism, and mitochondrial bioenergetics.
The STAT3/HIF-1α/PTRF-axis in neurons, aggravating cerebral I/R injury by regulating the activity and stability of PLA2G4A, might be a novel therapeutic target for ischemic stroke
((Jin W, Zhao J, Yang E, Wang Y, Wang Q, Wu Y, Tong F, Tan Y, Zhou J, Kang C. Neuronal STAT3/HIF-1α/PTRF axis-mediated bioenergetic disturbance exacerbates cerebral ischemia-reperfusion injury via PLA2G4A. Theranostics. 2022 Apr 4;12(7):3196-3216. doi: 10.7150/thno.71029. PMID: 35547748; PMCID: PMC9065197.))