phenylboronic_acid [Neurosurgery Wiki]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
Phenylboronic acid or benzeneboronic acid, abbreviated as PhB(OH)₂ where Ph is the phenyl group C₆H₅-, is a boronic acid containing a phenyl substituent and two hydroxyl groups attached to boron. Phenylboronic acid is a white powder and is commonly used in organic synthesis
----
Although injectable [[hydrogel]]s show promise for promoting healing of [[lesion]]s and health of surrounding [[tissue]], enabling cellular [[ingrowth]] and restoring [[neural tissue]] continue to be challenging. 
Hu et al. hypothesized that these challenges arise in part from the mismatch of composition, stiffness and [[viscoelasticity]] between the hydrogel and the brain [[parenchyma]], and tested this [[hypothesis]] by developing and evaluating a self-healing hydrogel that not only mimicked the composition, but also the stiffness and viscoelasticity of native [[brain parenchyma]]. The hydrogel was crosslinked by dynamic boronate ester bonds between [[phenylboronic acid]] grafted [[hyaluronic acid]] (HA-PBA) and dopamine grafted [[gelatin]] (Gel-Dopa). This HA-PBA/Gel-Dopa hydrogel could be injected into a lesion [[cavity]] in a shear-thinning manner with rapid [[hemostasis]], high tissue [[adhesion]] and efficient self-healing. They tested this in an [[in vivo]] [[mouse model]] of brain lesions and found the multi-functional injectable hydrogel to support neural cell [[infiltration]], decrease [[astrogliosis]] and glial [[scar]]s, and close the lesions. The results suggest a role for [[extracellular matrix]]-mimicking [[viscoelasticity]] in [[brain lesion]] healing, and motivate additional [[experimentation]] in larger [[animal]]s as the technology progresses towards potential application in humans
((Hu Y, Jia Y, Wang S, Ma Y, Huang G, Ding T, Feng D, Genin GM, Wei Z, Xu F. An ECM-Mimicking, Injectable, Viscoelastic Hydrogel for Treatment of Brain Lesions. Adv Healthc Mater. 2022 Nov 18:e2201594. doi: 10.1002/adhm.202201594. Epub ahead of print. PMID: 36398536.)).
----