crmp2 [Neurosurgery Wiki]

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Abe et al. found that facilitated experience-driven synaptic glutamate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic-acid) receptor delivery and resulted in the acceleration of motor function recovery after motor cortex cryoinjury in mice in a training-dependent manner through cortical reorganization. [[Edonerpic maleate]] bound to [[Collapsin response mediator protein family]] 2 ([[CRMP2]]) and failed to augment recovery in CRMP2-deficient mice. [[Edonerpic maleate]] enhanced motor function recovery from internal capsule hemorrhage in nonhuman primates. Thus, edonerpic maleate, a neural plasticity enhancer, could be a clinically potent small compound with which to accelerate rehabilitation after brain damage
((Abe H, Jitsuki S, Nakajima W, Murata Y, Jitsuki-Takahashi A, Katsuno Y, Tada
H, Sano A, Suyama K, Mochizuki N, Komori T, Masuyama H, Okuda T, Goshima Y, Higo 
N, Takahashi T. CRMP2-binding compound, edonerpic maleate, accelerates motor
function recovery from brain damage. Science. 2018 Apr 6;360(6384):50-57. doi:
10.1126/science.aao2300. PubMed PMID: 29622647.
)).