Cerebral perfusion [Neurosurgery Wiki]

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=====Cerebral perfusion=====
Defined as the steady-state delivery of nutrients and oxygen via blood to brain tissue parenchyma
per unit volume and is typically measured in milliliters per 100 g of tissue per minute. 
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[[Perfusion computed tomography]] (CT) is a technique that allows rapid qualitative and quantitative evaluation of [[cerebral perfusion]] by generating maps of [[cerebral blood flow]] (CBF), [[cerebral blood volume]] (CBV), and [[mean transit time]] (MTT).
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[[Hypertonic saline]] avoids the diuretic effect of [[mannitol]] while still being effective at reducing brain water. After administration, [[cerebral perfusion]] may actually be increased 
((Qureshi AI, Suarez JI. Use of hypertonic saline solutions in treatment of cerebral edema and intracranial hypertension. Crit Care Med. 2000;28:3301–3313. doi: 10.1097/00003246-200009000-00032.)).
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[[Apolipoprotein E]] (APOEε4) may induce [[cerebral perfusion]] impairment in the early phase, contributing to early [[brain injury]] (EBI) following [[aneurysmal subarachnoid hemorrhage]] (aSAH), and assessment of APOE genotypes could serve as a useful tool in the prognostic evaluation and therapeutic management of aSAH
((Cheng C, Jiang L, Yang Y, Wu H, Huang Z, Sun X. Effect of APOE Gene
Polymorphism on Early Cerebral Perfusion After Aneurysmal Subarachnoid
Hemorrhage. Transl Stroke Res. 2015 Sep 14. [Epub ahead of print] PubMed PMID:
26370543.
)).