Automated anesthesia [Neurosurgery Wiki]

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====== Automated anesthesia ======

Automated [[anesthesia]] systems that continuously monitor [[cortical excitability]] (CE) changes to govern drug infusion rates, are desirable. Paired-pulse transcranial magnetic stimulation (ppTMS), with electromyography (EMG), provides noninvasive CE measures. We tested whether, and with what temporal resolution, ppTMS-EMG detects dose-dependent CE in rats anesthetized with continuous intravenous propofol. Motor-evoked potentials (MEPs) were recorded every 20 seconds as either propofol bolus or change in infusion rate was applied. ppTMS-derived measures varied in direct proportion to propofol dose with subminute temporal resolution. We conclude that ppTMS-EMG enables real-time markers of target engagement by anesthetics that may be incorporated into an automated device
((Gersner R, Paredes C, Hameed MQ, Dhamne SC, Pascual-Leone A, Rotenberg A.
Transcranial magnetic stimulation tracks subminute changes in cortical
excitability during propofol anesthesia. Ann Clin Transl Neurol. 2020 Feb 15.
doi: 10.1002/acn3.50981. [Epub ahead of print] PubMed PMID: 32061019.
)).

===== Unclassified =====

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