temporal_lobe_dysembryoplastic_neuroepithelial_tumor

Dysembryoplastic Neuroepithelial Tumor (DNET) - Temporal Lobe

Dysembryoplastic Neuroepithelial Tumor (DNET) is a benign, WHO grade I glioneuronal tumor typically presenting in children and young adults with long-standing, pharmacoresistant epilepsy. The temporal lobe is the most common location.

  • Age: Childhood to young adulthood (most < 20 years)
  • Slight male predominance
  • ~80% of cases involve the temporal lobe
  • Chronic, intractable focal epilepsy
  • Often normal neurological exam
  • Rarely causes increased intracranial pressure or neurological deficits
  • Surgical resection is the treatment of choice
  • Gross total resection often cures epilepsy
  • Recurrence is rare
  • Excellent long-term prognosis
  • Very low risk of malignant transformation
  • Seizure freedom in >80% after complete resection
  • Ganglioglioma
  • Oligodendroglioma (especially low-grade)
  • Cortical dysplasia without tumor
  • Low-grade astrocytoma
  • WHO Classification of Tumors of the CNS, 2021
  • Guerrini R, et al. Epilepsy surgery and DNETs. Epilepsia. 2012.
  • Blumcke I, et al. Histopathological findings in long-term epilepsy surgery. Brain Pathol. 2007.
  • temporal_lobe_dysembryoplastic_neuroepithelial_tumor.txt
  • Last modified: 2025/07/11 06:40
  • by administrador