Telomerase Activation

An enzyme called telomerase can slow, stop or even reverse the telomere shortening that happens as we age.

Exposing human cells to telomerase slows cell aging and allows cells to begin copying again

In gliomas, TERT expression and TERT promoter mutation are considered to reliably indicate telomerase activation, while ATRX mutation and/or loss indicates an alternative lengthening of telomeres (ALT). However, these relationships have not been extensively validated in tumor tissues.