The TAM family of RTKs, consisting of Tyro3, Axl, and MerTK, is prominently expressed during the development and function of the central nervous system (CNS). Aberrant expression and dysregulated activation of TAM family members has been demonstrated in a variety of CNS-related disorders and diseases, including the most common but least treatable brain cancer in children and adults: glioblastoma multiforme 1).
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Pierce AM, Keating AK. TAM receptor tyrosine kinases: expression, disease and
oncogenesis in the central nervous system. Brain Res. 2014 Jan 13;1542:206-20.
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24184575; PubMed Central PMCID: PMC4141466.