Stachybotrys microspora triprenyl phenol-7 (SMTP-7) is a new thrombolytic agent that exhibits anti-inflammatory effects.
The hemorrhagic transformation was fewer with SMTP-7 than with recombinant tissue plasminogen activator (rt-PA) following ischemia-reperfusion in animal models.
SMTP-7 decreases mortality, hemorrhagic transformation, and neurological deficits, and can be a safe thrombolytic agent following MCAO under the warfarin-treated condition 1).
1)
Ito A, Niizuma K, Shimizu H, Fujimura M, Hasumi K, Tominaga T. SMTP-7, a new
thrombolytic agent, decreases hemorrhagic transformation after transient middle
cerebral artery occlusion under warfarin anticoagulation in mice. Brain Res. 2014
Jul 9. pii: S0006-8993(14)00911-1. doi: 10.1016/j.brainres.2014.07.004. [Epub
ahead of print] PubMed PMID: 25016287.