SETDB1
This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.
A research clarified that SETDB1 regulates of tumor microenvironment and hence presents a potential therapeutic target for glioblastoma treatment 1)
This article was retracted 2)
OLIG2-SETDB1 complex can mediate transcriptional repression in oligodendrocytes progenitor cells, affecting myelination 3).
A study suggests that the PELP1/SETDB1 axis play an important role in aberrant Akt activation and serves as a novel target for treating endocrine therapy resistance in breast cancer 4).