Pineal region tumor epidemiology

• Adult pineoblastoma: A prospective study and twelve-year experience from three tertiary care cancer institutes of India depicting the effect of various independent parameters and therapeutic strategy on progression and survival in this extremely rare malignancy
• The establishment of machine learning prognostic prediction models for pineal region tumors based on SEER-A multicenter real-world study
• Germline Pathogenic DROSHA Variants Are Linked to Pineoblastoma and Wilms Tumor Predisposition
• The microsurgical infratentorial supracerebellar approach for lesions of the pineal gland: feasibility, morbidity, and functional outcomes from a single-center experience
• Prognosis of Pineal Region Tumors in Children: A Population-Based Study
• Long-Term Outcomes of Stereotactic Radiosurgery for Pineocytomas: An International Multicenter Study
• Microsurgical Management of Pineal Region Tumors
• Simultaneous Single-Trajectory Endoscopic Biopsy and Third Ventriculostomy in Pineal Region Tumors: A Systematic Review and Single Arm Meta-Analysis

Pineal region tumors (PRTs), which are rare tumors, account for approximately 0.4-1.0% of intracranial tumors.

Pineal parenchymal tumors (PPTs) are even rarer, and approximately 30% of PPTs occur in neoplasms of the pineal region ¹⁾.

Over the age of 40 is more likely to be a meningioma or a glioma.

Tumors in this region are more common in children (3–8% of pediatric brain tumors) than in adults (≤1%). ²⁾

Over 17 tumor types occur in this region ³⁾.

Pineal germinoma is the most common tumor (21– 44% in American/European population, 43–70% in Japan), followed by pineal astrocytoma, pineal teratoma and pineoblastoma ⁴⁾.

Many tumors are of mixed cell type.

Germ cell tumors (GCT), ependymomas and pineal cell tumors metastasize easily through the CSF (“drop metastases”).