This is an old revision of the document!
Nuclear Receptor Binding Protein 1
Gene: NRBP1 Full name: Nuclear Receptor Binding Protein 1 Type: Pseudokinase / Adaptor protein Cellular location: Involved in trafficking between the endoplasmic reticulum and Golgi apparatus
🧬 Main Functions
- Regulates intestinal epithelial architecture via Wnt-responsive genes
- Functions in cellular signaling despite lacking classic catalytic activity
- Involved in protein homodimerization and intracellular transport
- May regulate apoptosis and cell proliferation
🔬 Biomedical Relevance
Cancer
- Glioblastoma: Promotes malignancy through PI3K/Akt pathway activation
- Triple-negative breast cancer: Acts via Rac1/Cdc42 signaling through P‑Rex1
- Colorectal cancer: Overexpression linked to improved survival (via JNK pathway)
- Prostate and bladder cancer: Associated with tumor progression
Non-oncological diseases
- Gout: Genetic variants increase susceptibility
- Triglycerides: Implicated in lipid metabolism regulation
Viral infections
- Interacts with viral proteins: Dengue (NS3), HIV‑1 (Gag)
- Alters host membranes to promote viral replication
🐭 Animal Model Studies
- Knockout mice are embryonically lethal (~E7.5) → essential in early development
🧪 Expression & Structure
- Highly expressed in: prostate, colon, brain, esophagus, testis
- Contains a pseudokinase domain (lacks known enzymatic activity)
- Several validated isoforms